Unfortunately, this feature is not available in the previous versions of NONMEM®. However, a more direct method to obtain the SE of EBE is possible with NONMEM® VI using one of the internal variables, POSTV. A Perl based automated utility to calculate the SE of EBE is available in PsN® version 2.2.6 or later. Writing one's own code requires careful thinking and programming expertise. Therefore postprocessing after a modeling NONMEM run is necessary to obtain the SE of EBE. The SE of EBE of the inter-subject variability parameter η is not available in the output file of NONMEM®. Also the SE of EBE can be used for simulation considering the uncertainty in the inter-subject variability. The SE of EBE is an enhanced model diagnosis tool to assess the precision of the estimated inter-subject variability parameter η. However the standard error (SE) of the empirical Bayes estimate (EBE) of the inter-subject variability parameter η is not provided in the NONMEM® output file. NONMEM® uses inter-subject variability parameter η to describe the individual differences in PK/PD parameters. NONMEM® (NONlinear Mixed Effects Model) is the most widely used software for the population pharmacokinetic/pharmacodynamic (PK/PD) modeling and simulation, also is the standard tool for drug development as well as regulatory approval.
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